Advances in Health Science Research
نویسنده
چکیده
The invention of thiazolidinediones, also referred to as glitazones, has been one of the greatest developments in the treatment of Type II diabetes over the last two decades. Although the efficacy of the glitazones is substantial, their use has been limited by adverse effects including edema, weight gain and cardiac issues. While still being used for a specific subset of diabetic patients, much effort is being expended to find other therapeutic uses for the glitazones, especially to take advantage of their anti-inflammatory benefits. Progress is also being made in the development of more selective PPARagonists that would offer the same efficacy as the thiazolidinediones, but with reduced adverse effects.
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